The house side allrounder Wiaan Mulder also handed ODI debuts into Aiden Markram, who impressed at the Test series. As JP Duminy, Hashim Amla and Dwaine Pretorius were all rested, Temba Bavuma returned to the side.
South Africa captain Faf du Plessis opted to bat with the intent of using an East London pitch that was slow.
Bangladesh was because of trauma, and Nasir Hossain, out without Tamim Iqbal. Mehedy Hasan and Soumya Sarkar showcased for the first time in this series from the ODI XI.
South Africa won the toss and elected to bat first.
South Africa: 1 Temba Bavuma 2 Quinton de Kock (wk), 3 Faf du Plessis (capt), 4 Aiden Markram, 5 AB de Villiers, 6 Farhaan Behardien, 7 Wiaan Mulder, 8 Andile Phehlukwayo, 9 Kagiso Rabada, 10 Dane Paterson, 11 Imran Tahir
Bangladesh: 1 Soumya Sarkar, 2 Imrul Kayes, 3 Liton Das (wk), 4 Shakib Al Hasan, 5 Mushfiqur Rahim, 6 Mahmudullah, 7 Sabbir Rahman, 8 Mehedy Hasan, 9 Mashrafe Mortaza (capt), 10 Taskin Ahmed, 11 Rubel Hossain
Bangladesh vs South Africa 3rd ODI Highlights:
Highlights will be coming soon.